Anna Weber-van Bosse has an LOA of 80 metres, a beam of 17 metres, a summer draught of five metres, a gross tonnage of 3,481, and accommodation for 16 crewmembers and 30 scientists. The vessel is fitted with a DP2 system while her hull has been strengthened to ice class 1C standard.
The vessel boasts a selection of laboratories including wet and dry labs, a CTD hangar, a large working deck, and a drop keel and gondola that can house larger sensors. Her electronics include single- and multi-beam echosounders and underwater positioning sensors from Kongsberg Maritime and acoustic Doppler current profilers from Nortek.
The propulsion system includes generators supplied by ABC. The generators are EU Stage V-compliant and can be configured in the future to permit operation on methanol.